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Heteronemin and Tetrac Induce Anti-Proliferation by Blocking EGFR-Mediated Signaling in Colorectal Cancer Cells.

Marine drugs - 27 Jul 2022

Unson Sukanya, Chang Tung-Cheng, Yang Yung-Ning, Wang Shwu-Huey, Huang Chi-Hung, Crawford Dana R, Huang Haw-Ming, Li Zi-Lin, Lin Hung-Yun, Whang-Peng Jacqueline, Wang Kuan, Davis Paul J, Li Wen-Shan

Abstract excerpt

Overexpressed EGFR and mutant K-Ras play vital roles in therapeutic resistance in colorectal cancer patients. To search for an effective therapeutic protocol is an urgent task. A secondary metabolite in the sponge Hippospongia sp., Heteronemin, has been shown to induce anti-proliferation in several types of cancers. A thyroxine-deaminated analogue, tetrac, binds to integrin αvβ3 to induce anti-proliferation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36005485
DOI: 10.3390/md20080482
PMCID: PMC9410344

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