Article

The C2 domain augments Ras GTPase Activating Protein catalytic activity

2024-08-29

Abstract excerpt

Regulation of Ras GTPases by GTPase activating proteins (GAP) is essential for their normal signaling. Nine of the ten GAPs for Ras contain a C2 domain immediately proximal to their canonical GAP domain, and in RasGAP (p120GAP, p120RasGAP; RASA1 ) mutation of this domain is associated with vascular malformations in humans. Here, we show that the C2 domain of RasGAP is required for full catalytic activity towards...

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Literature Corpus work: 9522e58c-6f68-55e0-b64f-964910e854b1
DOI: 10.1101/2024.08.29.609784

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