Article

Clinically observed <i>RASA1</i> missense mutants exhibit diverse RasGAP protein behaviors

2025-10-04

Abstract excerpt

The RASA1 gene is mutated in cerebrovascular disorders and cancer, yet how the resulting mutations in the GTPase Activating Protein, RasGAP (p120RasGAP, RASA1) dysregulate signaling remains poorly understood. Here, we catalogue currently reported disease-associated mutations in RASA1 and assess their impact on RasGAP protein in vitro . On mapping these mutations onto experimental structures and structural model...

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Literature Corpus work: d283e382-b996-557b-a39c-da87e1487a36
DOI: 10.1101/2025.10.03.680326

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