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Bacterial DNA promotes Tau aggregation

11 Feb 2020

Abstract excerpt

A hallmark feature of Alzheimer's disease (AD) and other tauopathies is the misfolding, aggregation and cerebral accumulation of tau deposits. Compelling evidence indicates that misfolded tau aggregates are neurotoxic, producing synaptic loss and neuronal damage. Misfolded tau aggregates are able to spread the pathology from cell-to-cell by a prion like seeding mechanism. The factors implicated in the initiation...

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PMID: 32047247
DOI: 10.1038/s41598-020-59364-x

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