Article

The Frizzled-ligand Norrin acts as a tumour suppressor linking oncogenic RAS signalling to p53

2019-06-11

Abstract excerpt

Tumour suppressor genes are frequently affected by somatic alterations in cancer, and the impairment of their normal function provides a strong contribution to tumourigenesis. Short-hairpin (sh) RNA library screens have been employed as powerful genetic tools to uncover important new players in human cancer 1–5 . To identify potential novel tumour suppressor genes acting in the p53 pathway, we performed an shRNA...

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Literature Corpus work: 94e48cbe-da91-5aa5-a55d-9b6c1115944e
DOI: 10.1101/666925

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