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Article

Wnt signaling: Ig-norrin the dogma.

Current biology : CB - 8 Jun 2004

Clevers Hans

Abstract excerpt

Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15182694
DOI: 10.1016/j.cub.2004.05.039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular genetics and targeted therapy of WNT-related human diseases (Review).Semantic proximity Read ↗

Retinoschisis and Norrie disease: a missing link.Semantic proximity Read ↗

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