Article
Genetic link between p53 and genes required for formation of the zonula adherens junction.
Cancer science - 1 May 2004
Yamaguchi Masamitsu, Hirose Fumiko, Inoue Yoshihiro H, Ohno Katsuhito, Yoshida Hideki, Hayashi Yuko, Deak Peter, Matsukage Akio
Abstract excerpt
Ectopic expression of human p53 in Drosophila eye imaginal disc cells induces apoptosis and results in a rough eye phenotype in the adult flies. We have screened Drosophila stocks to identify mutations that enhance or suppress the p53-induced rough eye phenotype. One of the dominant enhancers of the p53-induced rough eye phenotype corresponds to a loss-of-function mutation of the crumbs gene, which is essential...
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