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Article

Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts.

Stem cells (Dayton, Ohio) - 1 May 2015

Kitajima Shunsuke, Kohno Susumu, Kondoh Atsushi, Sasaki Nobunari, Nishimoto Yuuki, Li Fengkai, Abdallah Mohammed Mohammed Salah, Muranaka Hayato, Nagatani Naoko, Suzuki Misa, Kido Yukiharu, Takahashi Chiaki

Abstract excerpt

Retinoblastoma tumor suppressor protein (RB) is inactivated more frequently during tumor progression than during tumor initiation. However, its exact role in controlling the malignant features associated with tumor progression is poorly understood. We established in vivo and in vitro models to investigate the undifferentiated state induced by Rb inactivation. Rb heterozygous mice develop well-differentiated...

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PMID: 25694388
DOI: 10.1002/stem.1971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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