Article
Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2018
Chen Fengju, Zhang Yiqun, Gibbons Don L, Deneen Benjamin, Kwiatkowski David J, Ittmann Michael, Creighton Chad J
Abstract excerpt
Purpose: The Cancer Genome Atlas data resources represent an opportunity to explore commonalities across cancer types involving multiple molecular levels, but tumor lineage and histology can represent a barrier in moving beyond differences related to cancer type.Experimental Design: On the basis of gene expression data, we classified 10,224 cancers, representing 32 major types, into 10 molecular-based "classes."...
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