Article

Enhancing Polygenic Risk Prediction by Modeling Quantile-Specific Genetic Effects

2025-12-29

Abstract excerpt

Polygenic risk scores (PRSs) quantify an individual’s genetic susceptibility to complex traits and diseases. Conventional PRSs, which are based on linear models, perform poorly for phenotypes with skewed distributions or with genetic effects that vary across the distribution. We propose a quantile regression-based PRS (QPRS) that can capture quantile-specific genetic effects. While existing PRSs provide only a sin...

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Literature Corpus work: 94b95afc-90b0-5b46-91d2-67a947791918
DOI: 10.64898/2025.12.25.25342935

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