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SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response

4 Dec 2021

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is essential for viral replication, making it a promising target for antiviral drug and vaccine development. SARS-CoV-2 infected patients exhibit an uncoordinated immune response; however, the underlying mechanistic details of this imbalance remain obscure. Here, starting from a functional proteomics workflow, we cataloged the...

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PMID: 34901782
DOI: 10.1016/j.isci.2021.103562

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