Article

Disruption of molecular interactions between G3BP1 stress granule host protein and nucleocapsid (NTD-N) protein impedes SARS-CoV-2 virus replication

2024-10-28

Abstract excerpt

<h4>ABSTRACT</h4> The Ras GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) serves as a formidable barrier to viral replication by generating stress granules (SGs) in response to viral infections. Interestingly, viruses, including SARS-CoV-2, have evolved defensive mechanisms to hijack SG proteins like G3BP1 for the dissipation of SGs that lead to the evasion of host’s immune responses. Previous rese...

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Literature Corpus work: 1e0a7b57-54c4-5acc-ad73-8e4e7e08cfc9
DOI: 10.1101/2024.10.27.620470

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