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Article

SARS-CoV-2 Nucleocapsid Protein Targets a Conserved Surface Groove of the NTF2-like Domain of G3BP1.

Journal of molecular biology - 15 May 2022

Biswal Mahamaya, Lu Jiuwei, Song Jikui

Abstract excerpt

Stress granule (SG) formation mediated by Ras GTPase-activating protein-binding protein 1 (G3BP1) constitutes a key obstacle for viral replication, which makes G3BP1 a frequent target for viruses. For instance, the SARS-CoV-2 nucleocapsid (N) protein interacts with G3BP1 directly to suppress SG assembly and promote viral production. However, the molecular basis for the SARS-CoV-2 N - G3BP1 interaction remains...

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Identifiers

PMID: 35240128
DOI: 10.1016/j.jmb.2022.167516
PMCID: PMC8882607

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