Article

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

2023-06-30

Abstract excerpt

G3BP1/2 are paralogous proteins that promote stress granule formation in response to cellular stresses, including viral infection. G3BP1/2 are prominent interactors of the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the functional consequences of the G3BP1-N interaction in the context of viral infection remain unclear. Here we used structural and biochemical a...

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Literature Corpus work: 13bf314f-64f9-550f-b92c-7f4fade82e4e
DOI: 10.1101/2023.06.29.546885

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