High Concentrations of Uric Acid Inhibit Endothelial Cell Migration via miR‐663 Which Regulates Phosphatase and Tensin Homolog by Targeting Transforming Growth Factor‐<i>β</i>1

Abstract excerpt

BACKGROUND: Whether microRNAs participate in endothelial dysfunction HUA remains unknown. A previous study indicated that miR-663 was the most significantly differentially expressed endothelial microRNA under HUA conditions. Some studies have demonstrated that the miR-663 target gene and TGF-β1, promoted endothelial cell migration by inhibiting PTEN deleted on chromosome 10. Therefore, we hypothesized that HUA...

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