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Article

Establishment and phenotypic characterization of a rat model with a clinically relevant phenotype for chronic gouty arthritis.

Frontiers in immunology - 1 Jan 2026

Xie Cunxiang, Huang Yidi, Fang Jinying, Liu Mingxuan, Gao Yingkai, Zhao Luming, Wang Hao, Yang Kaiyuan, Wang Hailong

Abstract excerpt

Background: The study of chronic gouty arthritis (CGA) is limited by the absence of animal models that faithfully mimic its chronic progression. Existing models fail to capture the transition from acute flares to chronic joint damage, highlighting the need for a more representative model. Methods: A novel CGA model was established in SD rats using a combined strategy. Chronic hyperuricemia was induced via a diet...

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Source

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Identifiers

PMID: 42079619
DOI: 10.3389/fimmu.2026.1752151
PMCID: PMC13132861

Genes

CGA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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