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Article

Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis.

PLoS biology - 1 Dec 2015

Griss Takla, Vincent Emma E, Egnatchik Robert, Chen Jocelyn, Ma Eric H, Faubert Brandon, Viollet Benoit, DeBerardinis Ralph J, Jones Russell G

Abstract excerpt

Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest as an antineoplastic agent. Recent work suggests that metformin directly antagonizes cancer cell growth through its actions on complex I of the mitochondrial electron transport chain (ETC). However, the mechanisms by which metformin arrests cancer cell proliferation remain poorly defined. Here we demonstrate that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26625127
DOI: 10.1371/journal.pbio.1002309
PMCID: PMC4666657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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