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Article

Targeting CCR1-mediated macrophage phenotypic switching to alleviate bladder pain and urinary dysfunction in interstitial cystitis.

Communications biology - 9 May 2026

Luo Ruixiang, Li Wenshuang, Liu Bolong, Huang Junlong, Ding Honglu, Zhang Chi, Li Xiaoyang, Wang Ziqiao, Liu Zheng, Zhou Xiangfu, Chen Jialiang

Abstract excerpt

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic inflammatory condition with limited treatments. Although macrophages are implicated in its pathogenesis, the mechanisms driving their phenotypic switching remain unclear. This study identifies CCR1's role in IC/BPS and evaluates CCR1 inhibition as a therapeutic strategy. Integrated bulk and single-cell RNA sequencing reveal enrichment of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42103951
DOI: 10.1038/s42003-026-10232-w
PMCID: PMC13376765

Genes

CCR1
CCL7
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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