Article

Contractile reprogramming of cardiac pericytes by MEK inhibition promotes arteriologenesis of the ischemic heart

2020-11-10

Abstract excerpt

<h4>Background</h4> The development of collateral arteries after a myocardial infarction (MI) was intensively studied, while the mechanism by which pericytes (PCs) contribute to arteriologenesis remains unexplored. This study aimed to 1) investigate if cardiac PCs gain functional features of contractile vascular smooth muscle cells (VSMCs) in vitro , and 2) determine if this potential can be evoked pharmacologic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 946b249e-904d-54c5-849d-c50244f87433
DOI: 10.1101/2020.11.10.376772

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Contractile reprogramming of cardiac pericytes by MEK inhibition promotes arteriologenesis of the ischemic heartDOI 10.1101/2020.11.10.376772Read

Cardiac Pericytes Acquire a Fibrogenic Phenotype and Contribute to Vascular Maturation After Myocardial Infarction.Semantic proximity Read

Vascularized Human Cardiac Organoids Reveal Endothelial–Cardiomyocyte Crosstalk and Mechanisms of Carfilzomib-Induced CardiotoxicitySemantic proximity Read

Spatiotemporal Transcriptomes of Pig Hearts Reveal Midkine-Mediated Vascularization in a Chronic Myocardial Infarcted ModelSemantic proximity Read

Specification and Diversification of Pericytes and Smooth Muscle Cells from MesenchymoangioblastsSemantic proximity Read

Dual Function of iPSC-Derived Pericyte-Like Cells in Vascularization and Fibrosis-Related Cardiac Tissue Remodeling In VitroSemantic proximity Read

Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiationSemantic proximity Read

Generation of functional vasculature from engraftable human pluripotent stem cell-derived progenitorsSemantic proximity Read

Molecular reprogramming of adventitial pericytes by a selective MEK inhibitor halts the progression of thoracic aortic aneurysmSemantic proximity Read

Naturally aligned cell delivery platform to augment post-infarction neovasculature and ventricular remodelingSemantic proximity Read

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesisSemantic proximity Read

Induced pluripotent stem cell derived pericytes respond to endogenous mediators of proliferation and contractilitySemantic proximity Read

Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heartSemantic proximity Read