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Article

Cardiac Pericytes Acquire a Fibrogenic Phenotype and Contribute to Vascular Maturation After Myocardial Infarction.

Circulation - 12 Sept 2023

Alex Linda, Tuleta Izabela, Hernandez Silvia C, Hanna Anis, Venugopal Harikrishnan, Astorkia Maider, Humeres Claudio, Kubota Akihiko, Su Kai, Zheng Deyou, Frangogiannis Nikolaos G

Abstract excerpt

BACKGROUND: Pericytes have been implicated in tissue repair, remodeling, and fibrosis. Although the mammalian heart contains abundant pericytes, their fate and involvement in myocardial disease remains unknown. METHODS: We used NG2Dsred;PDGFRαEGFP pericyte:fibroblast dual reporter mice and inducible NG2CreER mice to study the fate and phenotypic modulation of pericytes in myocardial infarction. The transcriptomic...

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Identifiers

PMID: 37350296
DOI: 10.1161/CIRCULATIONAHA.123.064155
PMCID: PMC10527624

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