Article
Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions.
The journal of investigative dermatology. Symposium proceedings - 1 Sept 2006
Eckes Beate, Zweers Manon C, Zhang Zhi Gang, Hallinger Ralf, Mauch Cornelia, Aumailley Monique, Krieg Thomas
Abstract excerpt
The extracellular matrix (ECM) environment in connective tissues provides fibroblasts with a structural scaffold and modulates cell shape, but it also profoundly influences the fibroblast phenotype. Here we studied fibroblasts cultured in a three-dimensional network of native collagen, which was either mechanically stressed or relaxed. Mechanical load induces fibroblasts that synthesize abundant ECM and a...
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