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A 2D inflammatory co-culture model for investigating synovial fibroblast and macrophage interactions in rheumatoid arthritis

17 Aug 2025

Abstract excerpt

Rheumatoid arthritis (RA), a chronic autoimmune disease, marked by sustained inflammation and joint destruction, largely driven by pathological interactions between fibroblast-like synoviocytes (FLS) and macrophages. Current in vitro and in vivo models fall short in replicating the complex synovial microenvironment of RA, hindering translational research. In this study, we developed a simplified yet...

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PMID: 40820240
DOI: 10.1038/s41598-025-16007-3

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