Article

Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance

2022-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Second generation antipsychotics (SGAs) are front-line treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not others. The mechanisms underlying this unpredictability in treatment efficacy remain unclear. All SGAs bind the D3 dopamine receptor (D3R) and are traditionally considered antagonists for dopamine receptor signaling. Here, we report that som...

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Literature Corpus work: 9444f7ef-51ad-5995-b4c6-b8bb8c056433
DOI: 10.1101/2022.08.17.504324

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