Article
Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1.
ACS chemical neuroscience - 15 Jul 2015
Manfra Ornella, Van Craenenbroeck Kathleen, Skieterska Kamila, Frimurer Thomas, Schwartz Thue W, Levy Finn Olav, Andressen Kjetil Wessel
Abstract excerpt
The human 5-HT7 serotonin receptor, a G-protein-coupled receptor (GPCR), activates adenylyl cyclase constitutively and upon agonist activation. Biased ligands differentially activate 5-HT7 serotonin receptor desensitization, internalization and degradation in addition to G protein activation. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.