Article

Impaired dendritic spike generation in the Fragile X prefrontal cortex is due to loss of dendritic sodium channels

2022-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Patients with Fragile X syndrome, the leading monogenetic cause of autism, suffer from impairments related to the prefrontal cortex including working memory and attention. Synaptic inputs to the distal dendrites of layer 5 pyramidal neurons in the prefrontal cortex have a weak influence on the somatic membrane potential. To overcome this filtering, distal inputs are transformed into local dendri...

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Literature Corpus work: 806adee2-d8d5-5867-80f7-a8fe4ca69afa
DOI: 10.1101/2022.05.11.491501

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