Article
A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development.
Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2021
Grubisha Melanie J, Sun Tao, Eisenman Leanna, Erickson Susan L, Chou Shinnyi, Helmer Cassandra D, Trudgen Melody T, Ding Ying, Homanics Gregg E, Penzes Peter, Wills Zachary P, Sweet Robert A
Abstract excerpt
Normally, dendritic size is established prior to adolescence and then remains relatively constant into adulthood due to a homeostatic balance between growth and retraction pathways. However, schizophrenia is characterized by accelerated reductions of cerebral cortex gray matter volume and onset of clinical symptoms during adolescence, with reductions in layer 3 pyramidal neuron dendritic length, complexity, and...
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