Article

Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator <i>POU2AF2</i>

2023-08-25

Abstract excerpt

Common genetic variation at 11q23.1 is associated with colorectal cancer (CRC) risk, and exerts local (cis) expression quantitative trait locus (cis-eQTL) effects on POU2AF2, COLCA1 and POU2AF3 genes. However, complex linkage disequilibrium and correlated expression at the 11q23.1 locus has thus far hindered elucidation of the mechanisms by which genetic variants impart CRC risk. Here, we establish that rs3087967...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9435e4e9-4f6e-5628-9689-4a619a170036
DOI: 10.1101/2023.08.24.554659

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator <i>POU2AF2</i>DOI 10.1101/2023.08.24.554659Read

Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2Semantic proximity Read

Characterization of cis-regulatory elements and functional variants in colorectal cancer using epigenomics and CRISPRi screenings.Semantic proximity Read

Multidimensional dissection of shared genetic susceptibility in ulcerative colitis and colorectal cancer: novel insights from integrative single-cell and multi-omics analysis.Semantic proximity Read

Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal CancerSemantic proximity Read

Genome-Wide Association and Transcriptome-Wide Association Studies Identify Novel Susceptibility Genes Contributing to Colorectal Cancer.Semantic proximity Read

Scarless genome editing reveals risk SNP rs6983267-G and lncRNA CCAT2 dictate targetable PI3K signaling dependence in WNT-dysregulated CRCSemantic proximity Read

Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk.Semantic proximity Read

Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer.Semantic proximity Read

Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1.Semantic proximity Read

Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis.Semantic proximity Read

Differential genetic influences over colorectal cancer risk and gene expression in large bowel mucosa.Semantic proximity Read

Multi-omics analysis to identify susceptibility genes for colorectal cancer.Semantic proximity Read