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Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis.

Carcinogenesis - 1 Sept 2014

Closa Adria, Cordero David, Sanz-Pamplona Rebeca, Solé Xavier, Crous-Bou Marta, Paré-Brunet Laia, Berenguer Antoni, Guino Elisabet, Lopez-Doriga Adriana, Guardiola Jordi, Biondo Sebastiano, Salazar Ramon, Moreno Victor

Abstract excerpt

In this study, we aim to identify the genes responsible for colorectal cancer risk behind the loci identified in genome-wide association studies (GWAS). These genes may be candidate targets for developing new strategies for prevention or therapy. We analyzed the association of genotypes for 26 GWAS single nucleotide polymorphisms (SNPs) with the expression of genes within a 2 Mb region (cis-eQTLs). Affymetrix...

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PMID: 24760461
DOI: 10.1093/carcin/bgu092
PMCID: PMC4146415

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