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Multiregion Cross-species Single-cell Multimodal Study of Prefrontal Cortex Reveals Cell-type Divergence and PTSD-associated Regulatory Landscapes

2025-09-11

Abstract excerpt

<title>Abstract</title> <p>The prefrontal cortex subregions—particularly the prelimbic (PLPFC) and infralimbic (ILPFC) cortices in rodents and dorsal anterior cingulate (dACC) and ventromedial prefrontal cortex (vmPFC) in humans—exhibit functionally specialized yet interconnected roles in PTSD pathogenesis. While PLPFC/dACC are implicated in fear memory, ILPFC/vmPFC are associated with fear extinction. However, t...

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Literature Corpus work: 9433a787-25d5-5e42-8734-ea02137ca20c
DOI: 10.21203/rs.3.rs-7451905/v1

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