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Article

Transcriptomic organization of the human brain in post-traumatic stress disorder.

Nature neuroscience - 1 Jan 2021

Girgenti Matthew J, Wang Jiawei, Ji Dingjue, Cruz Dianne A, Stein Murray B, Gelernter Joel, Young Keith A, Huber Bertrand R, Williamson Douglas E, Friedman Matthew J, Krystal John H, Zhao Hongyu, Duman Ronald S

Abstract excerpt

Despite extensive study of the neurobiological correlates of post-traumatic stress disorder (PTSD), little is known about its molecular determinants. Here, differential gene expression and network analyses of four prefrontal cortex subregions from postmortem tissue of people with PTSD demonstrate extensive remodeling of the transcriptomic landscape. A highly connected downregulated set of interneuron transcripts...

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PMID: 33349712
DOI: 10.1038/s41593-020-00748-7

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