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Cross-species Multimodal Single-cell Profiling of Dorsal and Ventral Prefrontal Cortex Reveals Cell-type Divergence and PTSD-associated Regulatory Landscapes

2025-07-28

Abstract excerpt

The prefrontal cortex subregions—particularly the prelimbic (PL) and infralimbic (IL) cortices in rodents and dorsal anterior cingulate (dACC) and ventromedial prefrontal cortex (vmPFC) in humans—exhibit functionally specialized yet interconnected roles in PTSD pathogenesis. While PL/dACC are implicated in fear acquisition, IL/vmPFC are associated with fear extinction. However, the inherent difference and cross-sp...

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Literature Corpus work: 6f560490-3ac8-5a88-a69e-6024950de490
DOI: 10.1101/2025.07.28.25332052

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