Article

Functional annotation of the human PTSD methylome identifies tissue-specific epigenetic variation across subcortical brain regions

2023-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Post-traumatic stress disorder is a mental disorder that may occur in the aftermath of severe psychological trauma. We examined 1,065,750 DNA methylation (DNAm) sites from 171 donors including neurotypicals, PTSD, and major depressive disorder cases across six areas implicated in the fear circuitry of the brain. We found significant differential methylation for PTSD near 195 genes and utilizing c...

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Literature Corpus work: 6b157f62-ef52-52d6-969b-0b903155b800
DOI: 10.1101/2023.04.18.23288704

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