Article

Loss of <i>Smad4</i> promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation

2021-04-29

Abstract excerpt

Over 85% of lung cancer patients harbor overt or subclinical metastases at diagnosis, and therefore most patients die of progressive metastatic disease despite aggressive local and systemic therapies. Somatic mutations in the Smad4 gene have been found in non-small-cell lung cancer, but the underlying mechanism by which Smad4 loss-of-function (LOF) accelerates lung cancer metastasis is yet to be elucidated. Here,...

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Literature Corpus work: 942b8ecf-1b3f-5517-b8f3-71bcfe61e1ed
DOI: 10.1101/2021.04.29.441956

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