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Article

Clinical outcome and expression of mutant P53, P16, and Smad4 in lung adenocarcinoma: a prospective study.

World journal of surgical oncology - 28 Mar 2015

Bian Chunan, Li Zhongyou, Xu Youtao, Wang Jie, Xu Lin, Shen Hongbing

Abstract excerpt

BACKGROUND: Whole-exome sequencing has shown that lung adenocarcinoma (LAC) can be driven by mutant genes, including TP53, P16, and Smad4. The aim of this study was to clarify protein alterations of P53, P16, and Smad4 and to explore their correlations between the protein alterations and clinical outcome. METHODS: We investigated associations among P53 mutant (P53(Mut)) expression, and P16 and Smad4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25890228
DOI: 10.1186/s12957-015-0502-0
PMCID: PMC4415338

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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