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Article

SMAD4 mutation correlates with poor prognosis in non-small cell lung cancer.

Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2021

Wang Yue, Xue Qianqian, Zheng Qiang, Jin Yan, Shen Xuxia, Yang Mu, Zhou Xiaoyan, Li Yuan

Abstract excerpt

SMAD4 is an intracellular signaling mediator of the TGF-β pathway. Its mutation was commonly observed in gastrointestinal cancers, such as pancreatic cancer. The loss of SMAD4 on immunohistochemical staining is often used to suggest a pancreaticobiliary differentiation in evaluating a metastatic adenocarcinoma with unknown origin. However, the function and molecular mechanism of SMAD4 in non-small cell lung...

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PMID: 33303972
DOI: 10.1038/s41374-020-00517-x

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