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Article

Two sides of the story? Smad4 loss in pancreatic cancer versus head‐and‐neck cancer

3 Feb 2012

Abstract excerpt

TGFβ signaling Smads (Smad2, 3, and 4) were suspected tumor suppressors soon after their discovery. Nearly two decades of research confirmed this role and revealed other divergent and cancer-specific functions including paradoxical tumor promotion effects. Although Smad4 is the most potent tumor suppressor, its functions are highly context-specific as exemplified by pancreatic cancer and head-and-neck cancer: in...

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PMID: 22321641
DOI: 10.1016/j.febslet.2012.01.054

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