A Multiparametric Activity Profiling Platform for Neuron Disease Phenotyping and Drug Screening

Abstract excerpt

<h4>ABSTRACT</h4> Patient stem cell-derived models enable imaging of complex disease phenotypes and the development of scalable drug discovery platforms. Current preclinical methods for assessing cellular activity do not, however, capture the full intricacies of disease-induced disturbances, and instead typically focus on a single parameter, which impairs both the understanding of disease and the discovery of eff...

Topics

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• Amyotrophic Lateral Sclerosis
• Dihydrotestosterone
• Drug Discovery
• Drug Evaluation, Preclinical
• Muscular Atrophy, Spinal
• Neurons
• Phenotype
• Receptors, Androgen

Identifiers and source

Literature Corpus work

9424b67c-46c0-5c80-a2a7-3df3903a2c96

DOI

10.1101/2021.06.22.449195