Article
Label-free morphological sub-population cytometry for sensitive phenotypic screening of heterogenous neural disease model cells.
Scientific reports - 16 Jun 2022
Imai Yuta, Iida Madoka, Kanie Kei, Katsuno Masahisa, Kato Ryuji
Abstract excerpt
Label-free image analysis has several advantages with respect to the development of drug screening platforms. However, the evaluation of drug-responsive cells based exclusively on morphological information is challenging, especially in cases of morphologically heterogeneous cells or a small subset of drug-responsive cells. We developed a novel label-free cell sub-population analysis method called "in silico FOCUS...
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