Article
A multiparametric activity profiling platform for neuron disease phenotyping and drug screening.
Molecular biology of the cell - 15 May 2022
Boivin Bruno, Roet Kasper C D, Huang Xuan, Karhohs Kyle W, Rohban Mohammad H, Sandoe Jack, Wiskow Ole, Maeda Rie, Grantham Alyssa, Dornon Mary K, Shao Jenny, Frost Devlin, Baker Dylan, Eggan Kevin, Carpenter Anne E, Woolf Clifford J
Abstract excerpt
Patient stem cell-derived models enable imaging of complex disease phenotypes and the development of scalable drug discovery platforms. Current preclinical methods for assessing cellular activity do not, however, capture the full intricacies of disease-induced disturbances and instead typically focus on a single parameter, which impairs both the understanding of disease and the discovery of effective...
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