Article

Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders

2025-02-18

Abstract excerpt

Most causal variants for neuropsychiatric disorders (NPD) remain unknown. A major hurdle is that disease variants may act in specific contexts, such as during neuronal activation, which is difficult to study in vivo at the population level. We profiled single-nucleus neuron-activation multiomics in human induced pluripotent stem cell (iPSC)-derived neurons from 100 donors, revealing the NPD-relevant transcriptomic...

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Literature Corpus work: 93f83969-0c2b-56b0-8c0a-a96aaad33e5e
DOI: 10.1101/2025.02.17.638682

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