Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss-of-function mutations in IFNAR2 in COVID-19 severe infection susceptibility.

Journal of global antimicrobial resistance - 1 Sept 2021

Smieszek Sandra P, Polymeropoulos Vasilios M, Xiao Changfu, Polymeropoulos Christos M, Polymeropoulos Mihael H

Abstract excerpt

Recent COVID-19 (coronavirus disease 2019) host genetics studies suggest enrichment of mutations in genes involved in the regulation of type I and type III interferon (IFN) immunity in patients with severe COVID-19 infection. We performed whole-genome sequencing analysis of samples obtained from patients participating in the ongoing ODYSSEY phase 3 study of hospitalised patients with severe COVID-19 infection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Mutation

Share to Receptor, Interferon alpha-beta

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 34273592
DOI: 10.1016/j.jgar.2021.06.005
PMCID: PMC8279933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss-of-function mutations in IFNAR2 in COVID-19 severe infection susceptibility.PMID 34273592Read ↗

Failure to replicate the association of rare loss-of-function variants in type I IFN immunity genes with severe COVID-19Semantic proximity Read ↗

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19.Semantic proximity Read ↗

IFNAR2 p.F8S Variant Associates with Severe COVID-19 and Adaptive Immune Cell Activation Modulation.Semantic proximity Read ↗

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19.Semantic proximity Read ↗

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.Semantic proximity Read ↗

Deleterious single nucleotide polymorphisms (SNPs) of human IFNAR2 gene facilitate COVID-19 severity in patients: a comprehensive in silico approach.Semantic proximity Read ↗

Genetic determinants of severe COVID-19 in young Asian and Middle Eastern patientsSemantic proximity Read ↗

A catalog of associations between rare coding variants and COVID-19 outcomesSemantic proximity Read ↗

Genetic determinants of severe COVID-19 in young Asian and Middle Eastern patients: a case series.Semantic proximity Read ↗

Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON).Semantic proximity Read ↗

Rare Variants in Inborn Errors of Immunity Genes Associated with Covid-19 SeveritySemantic proximity Read ↗

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.