Article

Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis

2023-01-03

Abstract excerpt

Cerebellar granule neurons (CGNs) are the most abundant neurons in the human brain and modulate cerebellar output to the motor cortex. Dysregulation of CGN development underlies movement disorders and medulloblastomas. It is suspected that these disorders arise in progenitor states of the CGN lineage, for which human models are lacking. Here, we have differentiated human hindbrain neuroepithelial stem (hbNES) cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93c7b33b-ab94-58fd-b5a1-c57405aa207e
DOI: 10.1101/2023.01.02.522503

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesisDOI 10.1101/2023.01.02.522503Read

Untangling mechanisms for cerebellar neural specification using human pluripotent stem cell-derived organoidsSemantic proximity Read

Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.Semantic proximity Read

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.Semantic proximity Read

Altered temporal sequence of transcriptional regulators in the generation of human cerebellar granule cellsSemantic proximity Read

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.Semantic proximity Read

Modeling Friedreich’s ataxia with Bergmann glia-enriched human cerebellar organoidsSemantic proximity Read

Identity and Nature of Neural Stem Cells in the Adult Human Subventricular ZoneSemantic proximity Read

A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem CellsSemantic proximity Read

Cerebellum- and forebrain-derived stem cells possess intrinsic regional character.Semantic proximity Read

Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cellsSemantic proximity Read

A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellumSemantic proximity Read

A Mesenchymal-Like ZEB1+ Niche Harbors Dorsal Radial Glial Fibrillary Acidic Protein-Positive Stem Cells in the Spinal CordSemantic proximity Read