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Article

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.

Cancer cell - 12 Aug 2008

Schüller Ulrich, Heine Vivi M, Mao Junhao, Kho Alvin T, Dillon Allison K, Han Young-Goo, Huillard Emmanuelle, Sun Tao, Ligon Azra H, Qian Ying, Ma Qiufu, Alvarez-Buylla Arturo, McMahon Andrew P, Rowitch David H, Ligon Keith L

Abstract excerpt

Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor cells is unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in multipotent and lineage-restricted central nervous system (CNS) progenitors. We observed that normal unipotent cerebellar granule neuron precursors (CGNPs) derive from hGFAP(+) and Olig2(+) rhombic lip progenitors. Hh activation in a...

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Identifiers

PMID: 18691547
DOI: 10.1016/j.ccr.2008.07.005
PMCID: PMC2597270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.PMID 18691547Read ↗

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