Article

Genetic algorithm-based personalized models of human cardiac action potential

2019-07-23

Abstract excerpt

We present a novel genetic algorithm-based solution to determine the set of cardiomyocyte model parameters based on experimental human action potential (AP) recordings. The novel approach is based on AP waveform dependence on the heart rate. In order to find the steady-state solution, optimized parameters include conductivities of ionic channels and exchangers augmented by slow variables, intracellular sodium conc...

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Literature Corpus work: 93c3907f-9625-57d3-954c-f2037b17901d
DOI: 10.1101/712406

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