Article

Personalization of mathematical models of human atrial action potential

2020-06-29

Abstract excerpt

Atrial cardiomyocytes demonstrate a wide spectrum of patient-specific, tissue-specific, and pathology-specific action potential (AP) phenotypes due to differences in protein expression and posttranslational modifications. Accurate simulation of the AP excitation and propagation in healthy or diseased atria requires a mathematical model capable of reproducing all the differences by parameter rescaling. In the prese...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cadd55cd-239b-578d-9896-a80986f9d4ff
DOI: 10.1101/2020.06.29.174870

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Personalization of mathematical models of human atrial action potentialDOI 10.1101/2020.06.29.174870Read

Genetic algorithm-based personalized models of human cardiac action potentialSemantic proximity Read

From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study.Semantic proximity Read

Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models.Semantic proximity Read

A Population Modelling Approach to Studying Age-Related Effects on Excitation-Contraction Coupling in Human CardiomyocytesSemantic proximity Read

A novel ionic model for matured and paced atrial–like hiPSC–CMs integrating <i>I</i> <sub> <i>Kur</i> </sub> and <i>I</i> <sub> <i>KCa</i> </sub> currentsSemantic proximity Read

Remodelling of potassium currents underlies arrhythmic action potential prolongation under beta-adrenergic stimulation in hypertrophic cardiomyopathySemantic proximity Read

Patient-Specific Heart Rate Modulates Developmental Electrophysiology in Transcriptomic-Guided In Silico Models of Pediatric Human Atrial CardiomyocytesSemantic proximity Read

Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and β-adrenergic signaling.Semantic proximity Read

Human Purkinje in silico model enables mechanistic investigations into automaticity and pro-arrhythmic abnormalitiesSemantic proximity Read

A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases.Semantic proximity Read

In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics.Semantic proximity Read

Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models.Semantic proximity Read