Article

Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production

2024-07-14

Abstract excerpt

Quiescence is a reversible cell cycle exit traditionally thought to be associated with a metabolically inactive state. Recent work in muscle cells indicates that metabolic reprogramming is associated with quiescence. Whether metabolic changes occur in cancer to drive quiescence is unclear. Using a multi-omics approach, we found that the metabolic enzyme ACSS2, which converts acetate into acetyl-CoA, is both highly...

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Identifiers and source

Literature Corpus work: 93bf3f4a-56bc-56f1-a61c-b97b44731cef
DOI: 10.1101/2024.07.12.603313

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