Article

Targeting IDH1 as a pro-senescent therapy in high-grade serous ovarian cancer

2018-11-17

Abstract excerpt

Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer. High-grade serous carcinoma (HGSC) is the most frequently diagnosed and lethal histosubtype of EOC. A significant proportion of HGSC patients relapse with chemoresistant disease. Therefore, there is an urgent need for novel therapeutic strategies for HGSC. Metabolic reprogramming is a hallmark of cancer cells, and targeting metabolism for cance...

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Literature Corpus work: 6c3c3926-0e28-530c-aa75-b703e57bf582
DOI: 10.1101/472613

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