Article

Adenosine triphosphate citrate lyase alters cellular myelocytomatosis oncogene signaling and fatty acid oxidation in residual breast cancer tumor tissues after neoadjuvant treatment

2026-04-23

Abstract excerpt

<title>Abstract</title> Background Metabolic adaptation enables breast cancer cells to develop neoadjuvant chemoendocrine therapy (NAC) resistance through metabolic alterations. Fatty acid oxidation (FAO) is a key metabolic pathway that facilitates the growth of resistant breast cancers. However, the mechanisms of FAO rewiring in NAC-resistant breast cancers remain unclear. Therefore, this study aimed to inve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ef3fc515-3c2f-5191-b65f-fe7b3f44eee6
DOI: 10.21203/rs.3.rs-9173952/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adenosine triphosphate citrate lyase alters cellular myelocytomatosis oncogene signaling and fatty acid oxidation in residual breast cancer tumor tissues after neoadjuvant treatmentDOI 10.21203/rs.3.rs-9173952/v1Read

Radiation-Induced Autophagy Regulates the Fibroblast Mitochondrial Stress Response and Crosstalk with Triple-Negative Breast Cancer CellsSemantic proximity Read

Endocrine persistence in ER+ breast cancer is accompanied by metabolic vulnerability in oxidative phosphorylationSemantic proximity Read

Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cellsSemantic proximity Read

Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy–Tolerant Persister Cells in ER+ Breast CancerSemantic proximity Read

Metabolic Switch in Endocrine Resistant Estrogen Receptor Positive Breast CancerSemantic proximity Read

ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis SensitivitySemantic proximity Read

Recurrent Breast Cancer Cells Depend on De novo Pyrimidine Biosynthesis to Suppress FerroptosisSemantic proximity Read

ACSS2-Mediated Metabolic-Epigenetic Crosstalk Drives Fulvestrant Resistance and Represents a Novel Therapeutic TargetSemantic proximity Read

AADAT-Driven Metabolic Control of Malate and CoQ 10 Shapes Immune Evasion in Triple-Negative Breast CancerSemantic proximity Read

Fatty acid metabolism provides an essential survival signal in OxPhos and BCR DLBCL cellsSemantic proximity Read

Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast CancerSemantic proximity Read

Optical imaging reveals chemotherapy-induced metabolic reprogramming of residual disease and recurrenceSemantic proximity Read