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Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells

17 Feb 2022

Abstract excerpt

Dormant cancer cells drive recurrence and drug resistance, which lead to poor prognosis in colorectal cancer (CRC). The mechanisms that regulate the entry of cancer cells into dormancy remain to be extensively studied. Nanog is a master transcription factor to maintain the self-renewal and pluripotency of stem cells. Since dormant cancer cells are similar to quiescent cancer stem cells, the correlation between...

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PMID: 35177584
DOI: 10.1038/s41419-022-04606-1

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