Article

PYK2 controls intestinal inflammation via activation of IRF5 in macrophages

2020-05-27

Abstract excerpt

Inflammatory bowel disease (IBD) is a group of inflammatory disorders of the gastro-intestinal tract caused by a complex combination of genetic and environmental factors. Interferon regulating factor 5 (IRF5) is a multifunctional regulator of immune responses, which plays a key pathogenic role in mouse colitis models and is a genetic risk factor for IBD. A screen of a protein kinase inhibitor library in macrophage...

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Literature Corpus work: 93ab8699-da3b-556f-85dc-171029464760
DOI: 10.1101/2020.05.24.113076

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